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LGS Treatments
Anti-Seizure Medications
There are 8 FDA-approved medications that treat seizures associated with LGS. There are also over 20 FDA-approved medications that treat specific seizure types found in epilepsy. Individuals with LGS are often on a cocktail of multiple medications to treat their seizures.
List of Treatments for Seizures
This page offers a list of FDA-approved treatments often used in those with LGS. Not all medications used in LGS are listed here. This list reflects U.S. FDA-approved medications.
Medication Treatments for Seizures in LGS
- Cannabidiol oral solutionEpidiolexOpens in a new tab
- CarbamazepineEpitol · Tegretol · CarbatrolOpens in a new tab
- ClobazamOnfi (pill) · Sympazan (dissolvable strip)Opens in a new tab
- FelbamateFelbatolOpens in a new tab
- FenfluramineFinteplaOpens in a new tab
- LamotrigineLamictalOpens in a new tab
- RufinamideBanzelOpens in a new tab
- TopiramateTopamax (pill) · Eprontia (liquid)Opens in a new tab
Medications for Seizures (not specifically for Seizures in LGS but for seizures in General)
- BrivaracetamBriviactOpens in a new tab
- CenobamateXcopriOpens in a new tab
- ClonazepamKlonopinOpens in a new tab
- Divalproex SodiumDepacon · DepakoteOpens in a new tab
- Divalproex Sodium-ERDepakote EROpens in a new tab
- Eslicarbazepine AcetateAptiomOpens in a new tab
- EthosuximideZarontinOpens in a new tab
- GabapentinNeurontinOpens in a new tab
- LacosamideVimpatOpens in a new tab
- LevetiracetamKeppraOpens in a new tab
- Levetiracetam XRKeppra XROpens in a new tab
- LorazepamAtivanOpens in a new tab
- OxcarbazepineOxtellar XR · TrileptalOpens in a new tab
- PerampanelFycompaOpens in a new tab
- PhenobarbitalPhenobarbitalOpens in a new tab
- PhenytoinDilantinOpens in a new tab
- PregabalinLyricaOpens in a new tab
- PrimidoneMysolineOpens in a new tab
- StiripentolDiacomitOpens in a new tab
- Tiagabine HydrochlorideGabitrilOpens in a new tab
- Topiramate XRQudexy XR · Trokendi XROpens in a new tab
- Valproic AcidDepakeneOpens in a new tab
- VigabatrinSabrilOpens in a new tab
- ZonisamideZonegran (pill) · Zonisade (liquid)Opens in a new tab
Medications for Seizure Clusters
Medications & Behavior in LGS
Learn how different anti-seizure medications may affect behavior, what changes to watch for, and questions to discuss with your neurologist.
View the Medications & Behavior in LGS Family Guide (PDF)
Opens LGS Foundation website
